Brains in motion -- computational modelling of the brain's waterscape

Marie E. Rognes

Chief Research Scientist & Research Professor of Numerical Analysis and Scientific Computing
Simula Research Laboratory

Seminar Information

Seminar Series
Fluid Mechanics, Combustion, & Engineering Physics

Seminar Date - Time
February 13, 2023, 3:00 pm
-
4:15

Seminar Location
Hybrid: In Person & Zoom (connection in link below)

Engineering Building Unit 2 (EBU2)
Room 479

Seminar Recording NOT Available

Marie E. Rognes sitting with hand on chin

Abstract

Your brain has its own waterscape: whether you are reading, thinking or sleeping, fluid flows through or around the brain tissue, clearing waste in the process. These biophysical processes are crucial for the well-being and function of the brain. In spite of their importance we understand them but little, and mathematical and computational modelling could play a crucial role in gaining new insight. In this talk, I will give an overview of mathematical, mechanical and numerical approaches to understand mechanisms underlying pulsatility, fluid flow and solute transport in the human brain. Topics include fluid-structure interactions, generalized poroelasticity, mixed finite element discretizations and preconditioning, uncertainty quantification, and optimal control.

Speaker Bio

Marie E. Rognes is Chief Research Scientist and Research Professor in Scientific Computing and Numerical Analysis at Simula Research Laboratory, Oslo, Norway and a 2022/2023 Fulbright Visiting Scholar at the Institute for Engineering in Medicine, University of California San Diego. She received her Ph.D from the University of Oslo in 2009 after an extended stay at the University of Minneapolis, Twin Cities, Minneapolis, US. She has been at Simula Research Laboratory since 2009, led its Department for Biomedical Computing from 2012-2016 and leads an interdisciplinary research team focusing on understanding the interplay between brain mechanics and neuroscience using mathematical and computational modelling. She has been awarded an ERC Starting Grant in Mathematics (2017-2023), won the 2015 Wilkinson Prize for Numerical Software, won the 2018 Royal Norwegian Society of Sciences and Letters Prize for Young Researchers within the Natural Sciences, is a member of the Norwegian Academy of Technological Sciences, was a Founding Member of the Young Academy of Norway and is a core developer and member of the FEniCS Steering Council.